Rinne A, Järvinen M, Räsänen O, Hopsu-Havu V K
Exp Pathol. 1984;26(2):67-70. doi: 10.1016/s0232-1513(84)80071-7.
Acid cysteine proteinase inhibitor (ACPI) and neutral cysteine proteinase inhibitor (NCPI) were localized in formalin-fixed normal human uterine portio as well as in the squamous cell carcinoma and dysplasias of the uterine portio. The peroxidase-antiperoxidase technique was used. In the squamous epithelium of normal uterine portio, ACPI and NCPI were localized in the cells of the upper and middle layers, mainly in the cytoplasm. In the precursors of cancer, immunoreactivity for ACPI and NCPI declined, and neither of the inhibitors was demonstrable immunohistochemically in the anaplastic squamo-epithelial carcinoma of the uterine portio. Our results suggest that ACPI and NCPI are associated with squamo-epithelial differentiation and that they may also be of significance for the regulation of cysteine proteinase activity in normal tissue and malignant growth.
酸性半胱氨酸蛋白酶抑制剂（ACPI）和中性半胱氨酸蛋白酶抑制剂（NCPI）定位于福尔马林固定的正常人体子宫颈以及子宫颈鳞状细胞癌和发育异常组织中。采用过氧化物酶-抗过氧化物酶技术。在正常子宫颈的鳞状上皮中，ACPI和NCPI定位于上层和中层细胞，主要位于细胞质中。在癌前病变中，ACPI和NCPI的免疫反应性下降，在子宫颈间变鳞状上皮癌中，这两种抑制剂均未通过免疫组织化学方法检测到。我们的结果表明，ACPI和NCPI与鳞状上皮分化有关，它们可能对正常组织和恶性生长中半胱氨酸蛋白酶活性的调节也具有重要意义。
