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受刺激的棕色脂肪组织中线粒体解偶联蛋白及其mRNA的快速增加。cDNA探针的应用。

Rapid increase of mitochondrial uncoupling protein and its mRNA in stimulated brown adipose tissue. Use of a cDNA probe.

作者信息

Ricquier D, Mory G, Bouillaud F, Thibault J, Weissenbach J

出版信息

FEBS Lett. 1984 Dec 10;178(2):240-4. doi: 10.1016/0014-5793(84)80608-0.

DOI:10.1016/0014-5793(84)80608-0
PMID:6548975
Abstract

The increase in mitochondrial uncoupling protein in brown adipose tissue during acute stimulation by exposure of animals to cold was examined. Uncoupling protein level increased during the first hours of tissue stimulation. Use of a cDNA probe shows that synthesis of uncoupling protein mRNA was quickly stimulated. Animals treated with propranolol exhibited neither increase in uncoupling protein mRNA nor increase in the protein itself.

摘要

研究了动物暴露于寒冷环境急性刺激期间棕色脂肪组织中线粒体解偶联蛋白的增加情况。在组织刺激的最初几个小时内，解偶联蛋白水平升高。使用cDNA探针显示解偶联蛋白mRNA的合成迅速受到刺激。用普萘洛尔处理的动物，其解偶联蛋白mRNA和蛋白本身均未增加。

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