肽YY和神经肽Y对人体胃排空的影响。

Effects of peptide YY and neuropeptide Y on gastric emptying in man.

作者信息

Allen J M, Fitzpatrick M L, Yeats J C, Darcy K, Adrian T E, Bloom S R

出版信息

Digestion. 1984;30(4):255-62. doi: 10.1159/000199117.

DOI:10.1159/000199117

Abstract

Neuropeptide Y (NPY) and peptide YY (PYY) are two structurally related peptides. PYY has been identified within endocrine cells and NPY within nerves of the gastrointestinal tract. Infusion of PYY at a low dose at a nominal rate of 2 pmol/kg/min resulted in an increment of 59.2 +/- 7.1 pmol/1 in plasma concentration and a significant delay in gastric emptying of glucose. Infusion of NPY at the same rate produced similar plasma concentrations (52.5 +/- 1.1 pmol/1) and had no significant effect on the rate of gastric emptying.

摘要

神经肽Y（NPY）和肽YY（PYY）是两种结构相关的肽。PYY已在胃肠道内分泌细胞中被发现，而NPY则存在于胃肠道神经中。以2 pmol/kg/min的标称速率低剂量输注PYY导致血浆浓度增加59.2±7.1 pmol/1，并显著延迟葡萄糖的胃排空。以相同速率输注NPY产生相似的血浆浓度（52.5±1.1 pmol/1），并且对胃排空速率没有显著影响。