Savage A P, Adrian T E, Carolan G, Chatterjee V K, Bloom S R
Gut. 1987 Feb;28(2):166-70. doi: 10.1136/gut.28.2.166.
The effect of an infusion of two doses of peptide YY (PYY), a novel putative gastrointestinal hormone, has been assessed on mouth to caecum intestinal transit time and on the rate of gastric emptying after ingestion of an inert 200 ml liquid meal thought unlikely to interrupt fasting gastrointestinal motility patterns. A low dose of PYY was chosen to give plasma concentrations within the range seen postprandially in healthy subjects, while the high dose mimicked the raised levels seen in several malabsorptive conditions. During infusion of PYY at 0.18 pmol/kg/min plasma concentrations rose from a basal of 8 +/- 2 pmol/l to 38 +/- 5 pmol/l and at 0.51 pmol/kg/min to 87 +/- 10 pmol/l. Mouth to caecum transit time was delayed from 67 +/- 4 mins on the saline infusion day to 94 +/- 7 mins (p less than 0.01) on the low dose and 192 +/- 9 mins (p less than 0.001) on the high dose infusion day. Time to 50% gastric emptying was prolonged from 37 +/- 8 mins during saline infusion to 63 +/- 10 mins (p less than 0.05) during low and 130 +/- 12 mins (p less than 0.001) during high dose infusion. Thus the infusion of PYY shows a dose related inhibition of mouth to caecum intestinal transit time and of the rate of gastric emptying and suggests this novel hormonal peptide to be of importance in gastrointestinal physiology.
一种新型的假定胃肠激素——肽YY（PYY），以两种剂量进行输注，其对口腔至盲肠的肠道转运时间以及摄入200毫升惰性液体餐（认为不太可能干扰禁食时的胃肠蠕动模式）后的胃排空速率的影响已得到评估。选择低剂量的PYY以使血浆浓度处于健康受试者餐后所见的范围内，而高剂量则模拟在几种吸收不良状况下所见的升高水平。在以0.18 pmol/kg/分钟的速度输注PYY期间，血浆浓度从基础值8±2 pmol/升升至38±5 pmol/升，在以0.51 pmol/kg/分钟的速度输注时升至87±10 pmol/升。口腔至盲肠的转运时间从输注生理盐水当天的67±4分钟延迟至低剂量输注日的94±7分钟（p<0.01）以及高剂量输注日的192±9分钟（p<0.001）。胃排空50%的时间从输注生理盐水期间的37±8分钟延长至低剂量输注期间的63±10分钟（p<0.05）以及高剂量输注期间的130±12分钟（p<0.001）。因此，PYY的输注显示出对口腔至盲肠肠道转运时间和胃排空速率的剂量相关抑制作用，并表明这种新型激素肽在胃肠生理学中具有重要意义。
