Heim M E, Swoboda M, Pahlke W, Edler L, Bicker U
J Cancer Res Clin Oncol. 1984;108(3):316-20. doi: 10.1007/BF00390465.
In 361 Sprague-Dawley rats autochthonous colorectal carcinomas were induced by intrarectal application of the carcinogen AMMN. Tumor-bearing animals were treated with a synthetic thioether-lysophospholipid (TLP) derivative and in combination chemotherapy with 5-fluorouracil (5-FU) and carmustine (BCNU). There was no difference in the survival time of treated and untreated animals. The median large-bowel tumor weight was significantly lower in the TLP/5-FU and TLP/5-FU/BCNU combination therapy groups than in the control groups. Transient hepatotoxicity was observed in the high-dosage (50 mg/kg body weight twice weekly) TLP group. This study confirmed the relative resistance of AMMN-induced colorectal carcinomas to antineoplastic treatment.
在361只Sprague-Dawley大鼠中，通过直肠内施用致癌物AMMN诱导原位结直肠癌。对荷瘤动物用合成硫醚-溶血磷脂（TLP）衍生物进行治疗，并与5-氟尿嘧啶（5-FU）和卡莫司汀（BCNU）联合化疗。治疗组和未治疗组动物的生存时间没有差异。TLP/5-FU和TLP/5-FU/BCNU联合治疗组的大肠肿瘤中位数重量显著低于对照组。在高剂量（每周两次，50mg/kg体重）TLP组中观察到短暂的肝毒性。本研究证实了AMMN诱导的结直肠癌对抗肿瘤治疗具有相对抗性。
