在单药化疗和联合化疗中使用硫醚溶血磷脂衍生物治疗自发性大鼠结肠腺癌
Treatment of autochthonous rat colonic adenocarcinomas with a thioether-lysophospholipid derivative in mono- and combination chemotherapy.
作者信息
Heim M E, Swoboda M, Pahlke W, Edler L, Bicker U
出版信息
J Cancer Res Clin Oncol. 1984;108(3):316-20. doi: 10.1007/BF00390465.
Abstract
In 361 Sprague-Dawley rats autochthonous colorectal carcinomas were induced by intrarectal application of the carcinogen AMMN. Tumor-bearing animals were treated with a synthetic thioether-lysophospholipid (TLP) derivative and in combination chemotherapy with 5-fluorouracil (5-FU) and carmustine (BCNU). There was no difference in the survival time of treated and untreated animals. The median large-bowel tumor weight was significantly lower in the TLP/5-FU and TLP/5-FU/BCNU combination therapy groups than in the control groups. Transient hepatotoxicity was observed in the high-dosage (50 mg/kg body weight twice weekly) TLP group. This study confirmed the relative resistance of AMMN-induced colorectal carcinomas to antineoplastic treatment.
摘要
在361只Sprague-Dawley大鼠中，通过直肠内施用致癌物AMMN诱导原位结直肠癌。对荷瘤动物用合成硫醚-溶血磷脂（TLP）衍生物进行治疗，并与5-氟尿嘧啶（5-FU）和卡莫司汀（BCNU）联合化疗。治疗组和未治疗组动物的生存时间没有差异。TLP/5-FU和TLP/5-FU/BCNU联合治疗组的大肠肿瘤中位数重量显著低于对照组。在高剂量（每周两次，50mg/kg体重）TLP组中观察到短暂的肝毒性。本研究证实了AMMN诱导的结直肠癌对抗肿瘤治疗具有相对抗性。
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