N-亚硝基乙酰氧基甲基甲胺和1,2-二甲基肼诱导的大鼠结肠肿瘤的化疗研究：5-氟尿嘧啶、替加氟、CGP 6809和CGP 15720A单药治疗
Chemotherapeutic studies on N-nitrosoacetoxymethyl-methylamine-and 1,2-dimethylhydrazine-induced colonic tumors in rats: monotherapy with 5-fluorouracil, ftorafur, CGP 6809, and CGP 15'720A.
作者信息
Wagner I, Habs M, Schmähl D, Amberger H, Bachmann U
出版信息
J Cancer Res Clin Oncol. 1982;104(1-2):115-31. doi: 10.1007/BF00402060.
Abstract
Colonic tumors were induced in male Sprague-Dawley rats by ten applications of 2 mg/kg/week N-nitrosoacetoxymethyl-methylamine (AMMN) or by three applications of 100 mg/kg/month 1,2-dimethylhydrazine (1,2-DMH). Application of AMMN and 1,2-DMH induced selective colonic tumors in 97% and 29-42% of the initial animals, respectively. Colonic-tumor-bearing animals were subjected to monotherapy with 5-fluorouracil, ftorafur, CGP 6809, and CGP 15'720A. No cures were achieved. The different therapies did not exert any clear influence on the survival time of animals, except for animals pretreated with AMMN and then subjected to ftorafur therapy.
摘要
通过每周10次给予2 mg/kg的N-亚硝基乙酰氧基甲基甲胺（AMMN）或每月3次给予100 mg/kg的1,2-二甲基肼（1,2-DMH），在雄性Sprague-Dawley大鼠中诱发结肠肿瘤。给予AMMN和1,2-DMH分别在97%和29%-42%的初始动物中诱发了选择性结肠肿瘤。对荷结肠肿瘤动物进行5-氟尿嘧啶、替加氟、CGP 6809和CGP 15720A的单一疗法治疗。未实现治愈。除先用AMMN预处理然后接受替加氟治疗的动物外，不同疗法对动物的生存时间没有明显影响。
相似文献
1
Chemotherapeutic studies on N-nitrosoacetoxymethyl-methylamine-and 1,2-dimethylhydrazine-induced colonic tumors in rats: monotherapy with 5-fluorouracil, ftorafur, CGP 6809, and CGP 15'720A.N-亚硝基乙酰氧基甲基甲胺和1,2-二甲基肼诱导的大鼠结肠肿瘤的化疗研究：5-氟尿嘧啶、替加氟、CGP 6809和CGP 15720A单药治疗
J Cancer Res Clin Oncol. 1982;104(1-2):115-31. doi: 10.1007/BF00402060.
2
Genetic factors controlling inheritance of susceptibility to 1,2-dimethylhydrazine.控制对1,2 - 二甲基肼易感性遗传的遗传因素。
J Cancer Res Clin Oncol. 1989;115(4):335-9. doi: 10.1007/BF00400959.
3
[Anticancer effect of levamisole and tegafur on 1,2-dimethylhydrazine (DMH)-induced colonic cancers in rats].
Nihon Gan Chiryo Gakkai Shi. 1982 Oct 20;17(7):1925-35.
4
Chemoprevention of development of colonic adenomatosis and carcinomatosis with 5-fluorouracil and ftorafur on animal model.在动物模型上用5-氟尿嘧啶和替加氟对结肠腺瘤病和癌病发生进行化学预防。
J Cancer Res Clin Oncol. 1980;97(3):223-32. doi: 10.1007/BF00405773.
5
Treatment of autochthonous rat colonic adenocarcinomas with a thioether-lysophospholipid derivative in mono- and combination chemotherapy.在单药化疗和联合化疗中使用硫醚溶血磷脂衍生物治疗自发性大鼠结肠腺癌
J Cancer Res Clin Oncol. 1984;108(3):316-20. doi: 10.1007/BF00390465.
6
Chemopreventive effect of Callistemon citrinus (Curtis) Skeels against colon cancer induced by 1,2-dimethylhydrazine in rats.柠檬桉（Curtis）Skeels 对二甲基肼诱导大鼠结肠癌的化学预防作用。
J Cancer Res Clin Oncol. 2019 Jun;145(6):1417-1426. doi: 10.1007/s00432-019-02905-3. Epub 2019 Mar 28.
7
Role of metformin in suppressing 1,2-dimethylhydrazine-induced colon cancer in diabetic and non-diabetic mice: effect on tumor angiogenesis and cell proliferation.二甲双胍在抑制糖尿病和非糖尿病小鼠中1,2 - 二甲基肼诱导的结肠癌中的作用：对肿瘤血管生成和细胞增殖的影响。
PLoS One. 2014 Jun 27;9(6):e100562. doi: 10.1371/journal.pone.0100562. eCollection 2014.
8
Different autochthonous models of colorectal cancer in the rat.大鼠结直肠癌的不同自发模型。
J Cancer Res Clin Oncol. 1986;111(2):157-9. doi: 10.1007/BF00400756.
9
[Effect of local moderate hyperthermia in combination with N-nitroso-1,3-bis-(2-chloroethyl)urea (BCNU) and 5-fluoro-(tetrahydro-2-furyl)uracil (ftorafur) on induced autochthonous colonic cancers in the rat. 3: Polychemotherapy in combination with hyperthermia].
Langenbecks Arch Chir. 1984;363(1):5-15. doi: 10.1007/BF01255773.
10
Effect of retinoids on the induction of colon cancer in F344 rats by N-methyl-N-nitrosourea or by 1,2-dimethylhydrazine.
Carcinogenesis. 1981;2(11):1167-72. doi: 10.1093/carcin/2.11.1167.
引用本文的文献
1
Treatment of autochthonous rat colonic adenocarcinomas with a thioether-lysophospholipid derivative in mono- and combination chemotherapy.在单药化疗和联合化疗中使用硫醚溶血磷脂衍生物治疗自发性大鼠结肠腺癌
J Cancer Res Clin Oncol. 1984;108(3):316-20. doi: 10.1007/BF00390465.
2
[Hyperthermia in oncology].[肿瘤学中的热疗]
Langenbecks Arch Chir. 1984;363(1):1-3. doi: 10.1007/BF01255772.
3
[Effect of local moderate hyperthermia in combination with N-nitroso-1,3-bis-(2-chloroethyl)urea (BCNU) and 5-fluoro-(tetrahydro-2-furyl)uracil (ftorafur) on induced autochthonous colonic cancers in the rat. 3: Polychemotherapy in combination with hyperthermia].
Langenbecks Arch Chir. 1984;363(1):5-15. doi: 10.1007/BF01255773.
4
Carcinogenicity of small doses of inhaled N-nitrosoacetoxymethyl-N-methylamine in Syrian golden hamsters.小剂量吸入N-亚硝基乙酰氧基甲基-N-甲胺对叙利亚金黄地鼠的致癌性
J Cancer Res Clin Oncol. 1986;111(2):108-9. doi: 10.1007/BF00400746.
5
Efficacy of beta-diketonato complexes of titanium, zirconium, and hafnium against chemically induced autochthonous colonic tumors in rats.钛、锆和铪的β-二酮络合物对大鼠化学诱导的原发性结肠肿瘤的疗效。
J Cancer Res Clin Oncol. 1987;113(5):446-50. doi: 10.1007/BF00390038.
6
Experimental colorectal cancer as a model of human disease.实验性结直肠癌作为人类疾病的模型。
Ann R Coll Surg Engl. 1987 Mar;69(2):48-53.
7
Alkyl phosphocholines: toxicity and anticancer properties.
Lipids. 1987 Nov;22(11):930-4. doi: 10.1007/BF02535558.
8
Comparative antitumor activity of ruthenium derivatives with 5'-deoxy-5-fluorouridine in chemically induced colorectal tumors in SD rats.
Cancer Chemother Pharmacol. 1987;19(4):347-9. doi: 10.1007/BF00261487.
本文引用的文献
1
Endoscopic diagnosis of chemically induced autochthonous colonic tumors in rats.
Hepatogastroenterology. 1981 Feb;28(1):53-7.
2
[Selective production of intestinal cancer in rats by 1,2-dimethylhydrazine].[1,2 - 二甲基肼在大鼠中选择性诱发肠癌]
Naturwissenschaften. 1967 Jun;54(11):285-6. doi: 10.1007/BF00620890.
3
Results of treatment of malignant tumors with ftorafur.用替加氟治疗恶性肿瘤的结果。
Cancer. 1972 Aug;30(2):390-2. doi: 10.1002/1097-0142(197208)30:2<390::aid-cncr2820300214>3.0.co;2-e.
4
Evaluation of endoscopic examination of colon tumors in rats.大鼠结肠肿瘤的内镜检查评估
Am J Dig Dis. 1975 Oct;20(10):928-34. doi: 10.1007/BF01070878.
5
Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples.需要对每位患者进行长期观察的随机临床试验的设计与分析。II. 分析与示例。
Br J Cancer. 1977 Jan;35(1):1-39. doi: 10.1038/bjc.1977.1.
6
Statistical methods for censored survival data.截尾生存数据的统计方法。
Environ Health Perspect. 1979 Oct;32:181-92. doi: 10.1289/ehp.7932181.
7
Chemotherapy studies in autochthonous rat tumors intestinal cancer.
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1978 Aug 24;92(1):105-17. doi: 10.1007/BF00284097.
8
Experimental investigations on the influence upon the chemical carcinogenesis. IIIrd communication: studies with 1,2-dimethylhydrazine.
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976 May 3;86(1):89-94. doi: 10.1007/BF00304938.
9
[On the carcinogenic action of N-nitroso-compounds. 5th Communication: acetoxymethyl-methyl-nitrosamine (author's transl)].[关于N-亚硝基化合物的致癌作用。第五篇通讯：乙酰氧基甲基-甲基亚硝胺（作者译）]
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976 Jan 2;85(1):47-9. doi: 10.1007/BF00308128.
Zotero 插件