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Antagonism of the effect of delta sleep-inducing peptide by naloxone in the rat.

作者信息

Young A M, Key B J

出版信息

Neuropharmacology. 1984 Nov;23(11):1347-50. doi: 10.1016/0028-3908(84)90058-3.

DOI:10.1016/0028-3908(84)90058-3
PMID:6549349
Abstract

The somnogenic properties of delta sleep-inducing peptide (DSIP) were investigated using electroencephalographic criteria. The peptide caused a significant increase in both REM and non-REM sleep at the expense of waking when injected into the lateral ventricle of the rat brain in four doses of 5 micrograms during the dark (waking) phase of the light/dark cycle. Furthermore this sleep promoting effect was blocked by pre-treatment with the opiate antagonist naloxone at a dose level (0.1 mg/Kg s.c.) considered selective for mu-receptors.

摘要

相似文献

1
Antagonism of the effect of delta sleep-inducing peptide by naloxone in the rat.
Neuropharmacology. 1984 Nov;23(11):1347-50. doi: 10.1016/0028-3908(84)90058-3.
2
The phosphorylated analogue of DSIP enhances slow wave sleep and paradoxical sleep in unrestrained rats.DSIP的磷酸化类似物可增强无束缚大鼠的慢波睡眠和异相睡眠。
Psychopharmacology (Berl). 1989;97(1):35-9. doi: 10.1007/BF00443409.
3
Effects of intracerebroventricular injection of delta sleep-inducing peptide (DSIP) and an analogue on sleep and brain temperature in rats at night.夜间脑室内注射δ-睡眠诱导肽（DSIP）及其类似物对大鼠睡眠和脑温的影响。
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4
Sleep-promoting effect following intracerebroventricular injection of a phosphorylated analogue of delta sleep-inducing peptide (DSIP-P) in rats.
Neurosci Lett. 1988 Aug 31;91(2):160-4. doi: 10.1016/0304-3940(88)90761-6.
5
Potent antinociceptive effect of centrally administered delta-sleep-inducing peptide (DSIP).中枢给予δ-睡眠诱导肽（DSIP）具有强大的抗伤害感受作用。
Eur J Pharmacol. 1988 Oct 18;155(3):247-53. doi: 10.1016/0014-2999(88)90510-9.
6
The effect of subcutaneous administration of delta sleep-inducing peptide (DSIP) on some parameters of sleep in the cat.皮下注射δ-睡眠诱导肽（DSIP）对猫睡眠某些参数的影响。
Physiol Behav. 1987;40(5):569-72. doi: 10.1016/0031-9384(87)90098-9.
7
Structure-activity relationship in the effects of delta-sleep-inducing peptide (DSIP) on rat sleep.δ-睡眠诱导肽（DSIP）对大鼠睡眠影响的构效关系
Pharmacol Biochem Behav. 1986 Apr;24(4):889-94. doi: 10.1016/0091-3057(86)90432-6.
8
Increased sleep following intracerebroventricular injection of the delta sleep-inducing peptide in rats.
Neurosci Lett. 1983 Sep 30;40(2):145-9. doi: 10.1016/0304-3940(83)90293-8.
9
[Opiate receptors and sleep. III. Effects of microinjections of DSIP (delta-sleep peptide) in the median thalamus, Periaqueductal gray matter and nucleus of the tractus solitarius of the rabbit (author's transl)].
Neuropsychobiology. 1981;7(6):321-5. doi: 10.1159/000117867.
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Some pharmacological effects of delta-sleep-inducing peptide (DSIP).δ-睡眠诱导肽（DSIP）的一些药理作用。
Eur Neurol. 1984;23(5):346-52. doi: 10.1159/000115712.

引用本文的文献

1
The phosphorylated analogue of DSIP enhances slow wave sleep and paradoxical sleep in unrestrained rats.DSIP的磷酸化类似物可增强无束缚大鼠的慢波睡眠和异相睡眠。
Psychopharmacology (Berl). 1989;97(1):35-9. doi: 10.1007/BF00443409.