Scherschlicht R, Aeppli L, Polc P, Haefely W
Eur Neurol. 1984;23(5):346-52. doi: 10.1159/000115712.
The synthetic nonapeptide DSIP was studied in rabbits and cats under normal conditions and under conditions of disturbed sleep. In other experiments, the effect of the oligopeptide on withdrawal jumping provoked by naloxone in morphine-dependent mice was studied. In rabbits, DSIP at 25 micrograms X kg-1 i.v. and 1 mg X kg-1 s.c. augmented spindle-dominated, light nonREM sleep and prevented hyposomnia after a stressful situation. In cats, 25 micrograms X kg-1 i.v. and 100 micrograms X kg-1 s.c. preferentially augmented REM sleep and abolished the sleep suppressant effect of morphine. In morphine-dependent mice, 25.5 micrograms X kg-1 i.v. as well as doses beyond 85 micrograms X kg-1 s.c. attenuated naloxone-induced withdrawal jumping. In most experimental situations, indications for bell-shaped dose-response curves of DSIP were found.
在正常条件下以及睡眠受到干扰的条件下，对家兔和猫体内的合成九肽DSIP进行了研究。在其他实验中，研究了该寡肽对吗啡依赖小鼠中由纳洛酮引发的戒断跳跃的影响。在家兔中，静脉注射25微克/千克和皮下注射1毫克/千克的DSIP可增强以纺锤波为主的轻度非快速眼动睡眠，并在应激状态后预防失眠。在猫中，静脉注射25微克/千克和皮下注射100微克/千克的DSIP优先增强快速眼动睡眠，并消除吗啡的睡眠抑制作用。在吗啡依赖小鼠中，静脉注射25.5微克/千克以及皮下注射超过85微克/千克的剂量可减轻纳洛酮诱导的戒断跳跃。在大多数实验情况下，发现了DSIP呈钟形剂量反应曲线的迹象。
