Chen L S, Ito T, Ogawa K, Shikano M, Satake T
Jpn Heart J. 1984 Nov;25(6):1001-9. doi: 10.1536/ihj.25.1001.
Plasma concentrations of 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) and thromboxane B2 (TXB2), the stable nonenzymatic metabolites of prostacyclin and TXA2, respectively, were assayed in 26 patients with essential hypertension and 25 normotensive subjects to investigate the pathophysiological role of prostacyclin and thromboxane A2 (TXA2) in essential hypertension. A tourniquet test was also performed on the upper limb of each subject to study the reactivity in peripheral vessels. In addition, platelet aggregation was investigated. There were significantly increased plasma TXB2 concentrations and platelet aggregation and significantly decreased plasma 6-keto-PGF1 alpha concentrations in patients with essential hypertension as compared with normotensive subjects. The responses to tourniquet tests were also different. There were significantly increased plasma concentrations of 6-keto-PGF1 alpha and TXB2 and platelet aggregation in normotensive subjects, but no significant changes with essential hypertension as compared to resting values. These results indicate that the reduction of plasma prostacyclin and increase of plasma TXA2 may contribute to the maintenance of blood pressure elevation in patients with essential hypertension. In addition, it is also suggested that increased prostacyclin generation in normotensive subjects during the tourniquet test is a protective mechanism. In patients with essential hypertension, the protective activity is reduced.
分别测定了26例原发性高血压患者和25例血压正常者血浆中6-酮-前列腺素F1α（6-keto-PGF1α）和血栓素B2（TXB2）的浓度，这两种物质分别是前列环素和血栓素A2的稳定非酶代谢产物，以研究前列环素和血栓素A2（TXA2）在原发性高血压中的病理生理作用。还对每位受试者的上肢进行了止血带试验，以研究外周血管的反应性。此外，还研究了血小板聚集情况。与血压正常者相比，原发性高血压患者血浆TXB2浓度和血小板聚集显著增加，血浆6-keto-PGF1α浓度显著降低。止血带试验的反应也有所不同。血压正常者血浆6-keto-PGF1α和TXB2浓度及血小板聚集显著增加，但与静息值相比，原发性高血压患者无显著变化。这些结果表明，血浆前列环素减少和血浆TXA2增加可能有助于原发性高血压患者维持血压升高。此外，还提示血压正常者在止血带试验期间前列环素生成增加是一种保护机制。在原发性高血压患者中，这种保护活性降低。
