急性心肌损伤犬一氧化碳与心室颤动阈值

Carbon monoxide and ventricular fibrillation threshold in dogs with acute myocardial injury.

作者信息

Aronow W S, Stemmer E A, Wood B, Zweig S, Tsao K P, Raggio L

出版信息

Am Heart J. 1978 Jun;95(6):754-6. doi: 10.1016/0002-8703(78)90506-9.

Abstract

In a blind, randomized study, the effect of breathing 100 p.p.m. of CO versus compressed, purified air for 2 hours on ventricular fibrillation threshold (VFT) was investigated in 21 dogs with acute myocardial injury. The mean arterial carboxyhemoglobin was 1.16 per cent in the air control period, 1.07 per cent after air, 1.08 per cent in the CO control period, and 6.34 per cent after CO. In comparison to air, CO increased the mean arterial carboxyhemoglobin (P less than 0.001). One dog developed spontaneous ventricular fibrillation 100 minutes after CO. Mean VFTs in the other 20 dogs were 12.8 +/- 6.8 milliamperes after CO, 11.2 +/- 6.0 milliamperes in the air control period, and 15.0 +/- 5.1 milliamperes after air. In comparison to air, CO decreased the VFT (P less than 0.001). These data show that breathing 100 p.p.m. of CO for 2 hours reduces the VFT in dogs with acute myocardial injury.

摘要

在一项双盲随机研究中，对21只急性心肌损伤犬，研究了吸入百万分之一百（100ppm）的一氧化碳（CO）与压缩净化空气2小时对心室颤动阈值（VFT）的影响。空气对照组期间平均动脉血碳氧血红蛋白为1.16%，空气对照组后为1.07%，一氧化碳对照组期间为1.08%，一氧化碳吸入后为6.34%。与空气相比，一氧化碳使平均动脉血碳氧血红蛋白增加（P<0.001）。一只犬在吸入一氧化碳后100分钟发生自发性心室颤动。其他20只犬的平均心室颤动阈值在吸入一氧化碳后为12.8±6.8毫安，空气对照组期间为11.2±6.0毫安，空气对照组后为15.0±5.1毫安。与空气相比，一氧化碳降低了心室颤动阈值（P<0.001）。这些数据表明，对于急性心肌损伤犬，吸入2小时百万分之一百（100ppm）的一氧化碳会降低心室颤动阈值。