Aronow W S, Stemmer E A, Zweig S
Arch Environ Health. 1979 May-Jun;34(3):184-6. doi: 10.1080/00039896.1979.10667394.
In a blind, randomized study, the effect of breathing 100 ppm of carbon monoxide versus compressed, purified air for 2 hr on ventricular fibrillation threshold was investigated in twenty anesthetized normal open-chested dogs. The mean arterial carboxyhemoglobin level was 1.12% in the air control period, 0.99% after air, 1.10% in the carbon monoxide control period, and 6.48% after carbon monoxide. Carbon monoxide increased the mean arterial carboxyhemoglobin (P less than .001). Mean ventricular fibrillation thresholds were 19.9 +/- 6.5 mA in the carbon monoxide control period, 15.7 +/- 5.6 mA after carbon monoxide 20.8 +/- 6.3 mA in the air control period, and 24.5 +/- 9.5 mA after air. Carbon monoxide decreased the ventricular fibrillation threshold (P less than .005). These data show that breathing 100 ppm of carbon monoxide for 2 hr reduces the ventricular fibrillation threshold in anesthetized normal open-chested dogs.
在一项双盲随机研究中，对20只麻醉状态下的正常开胸犬，研究了吸入100 ppm一氧化碳与压缩净化空气2小时对心室颤动阈值的影响。空气对照组期间平均动脉血碳氧血红蛋白水平为1.12%，空气组后为0.99%，一氧化碳对照组期间为1.10%，一氧化碳组后为6.48%。一氧化碳使平均动脉血碳氧血红蛋白水平升高（P＜0.001）。一氧化碳对照组期间平均心室颤动阈值为19.9±6.5 mA，一氧化碳组后为15.7±5.6 mA，空气对照组期间为20.8±6.3 mA，空气组后为24.5±9.5 mA。一氧化碳降低了心室颤动阈值（P＜0.005）。这些数据表明，吸入100 ppm一氧化碳2小时会降低麻醉状态下正常开胸犬的心室颤动阈值。
