Stambaugh J E, Hemphill D M, Wainer I W, Schwartz I
Lancet. 1977 Feb 19;1(8008):398-9. doi: 10.1016/s0140-6736(77)92606-x.
The concomitant administration of pethidine (meperidine) and phenobarbitone results in enhanced sedation in a patient previously tolerant of pethidine. A complete analysis of pethidine kinetics and metabolism was performed in this patient, in four additional patients undergoing similar treatment but not receiving phenobarbitone, and in a volunteer after placebo and phentobarbitone pretreatment. The results indicate that phentobarbitone enhances the production of the toxic metabolite norpethidine by increasing N-demethylation.
哌替啶（度冷丁）与苯巴比妥同时给药会使一名先前对哌替啶耐受的患者镇静作用增强。对该患者、另外四名接受类似治疗但未服用苯巴比妥的患者以及一名接受安慰剂和苯巴比妥预处理的志愿者进行了哌替啶动力学和代谢的全面分析。结果表明，苯巴比妥通过增加N-去甲基化作用增强了有毒代谢产物去甲哌替啶的生成。
