Gasset A R, Houde W L, Garcia-Bengochea M
Am J Ophthalmol. 1978 Mar;85(3):339-41. doi: 10.1016/s0002-9394(14)77725-6.
We studied 162 keratoconus patients in an attempt to clarify the role of hard contact lens wear in the development of keratoconus. Forty-three (26.5%) of these 162 patients developed keratoconus while wearing hard contact lenses. In a group of 1,248 controls who were fitted for soft contact lenses and observed by us from one year to six years, only one patient developed keratoconus. We demonstrated a circumstantial association between hard contact lens wear and the development of keratoconus, but no cause-effect relationship can be drawn from the existing data. However, we concluded that hard contact lenses do not retard or halt progression of the cone. Hard contact lens wear could not be ruled out as the specific environmental risk factor triggering keratoconus in 26.5% of the patients. If we identify the genetic risk present in this subpopulation, eliminating environmental risks would be an effective means of preventing keratoconus in those predisposed individuals.
我们研究了162名圆锥角膜患者，试图阐明佩戴硬性角膜接触镜在圆锥角膜发病过程中的作用。这162名患者中有43名（26.5%）在佩戴硬性角膜接触镜时患上了圆锥角膜。在一组由我们观察了一至六年、佩戴软性角膜接触镜的1248名对照者中，只有一名患者患上了圆锥角膜。我们证明了佩戴硬性角膜接触镜与圆锥角膜发病之间存在一种间接关联，但现有数据无法得出因果关系。然而，我们得出结论，硬性角膜接触镜不会延缓或阻止圆锥的进展。在26.5%的患者中，不能排除佩戴硬性角膜接触镜是引发圆锥角膜的特定环境风险因素。如果我们识别出这一亚群体中存在的遗传风险，消除环境风险将是预防那些易感个体患圆锥角膜的有效手段。
