Fulton A B, Craft J L, Howard R O, Albert D M
Am J Ophthalmol. 1978 May;85(5 Pt 1):690-8. doi: 10.1016/s0002-9394(14)77107-7.
We studied the ultrastructure of the four types of dysplastic rosettes and compared them with retinoblastoma rosettes. Dysplastic rosettes have morphologic characteristics intermediate between the normal photoreceptor layer and retino-blastoma rosettes; Müller cells contribute to the formation of dysplastic but not neoplastic rosettes. Abnormality in the relationship between the retina and the retinal pigment epithelium is frequent in cases with spontaneously occurring retinal dsyplasia and is consistent with previous observations that the retinal pigment epithelium influences the development of retinal morphology and function. We believe the normal developmental sequence of cell death and disappearance of necrotic cells may have gone awry in retinal dysplasia.
我们研究了四种发育异常的菊形团的超微结构，并将它们与视网膜母细胞瘤菊形团进行了比较。发育异常的菊形团具有介于正常光感受器层和视网膜母细胞瘤菊形团之间的形态学特征； Müller细胞参与发育异常而非肿瘤性菊形团的形成。在自发性视网膜发育异常的病例中，视网膜与视网膜色素上皮之间的关系异常很常见，这与之前关于视网膜色素上皮影响视网膜形态和功能发育的观察结果一致。我们认为，细胞死亡和坏死细胞消失的正常发育顺序在视网膜发育异常中可能出现了紊乱。
