Rosenstein B J, Langbaum T S
J Pediatr Gastroenterol Nutr. 1983 May;2(2):299-301.
A variety of intestinal complications, including constipation, abdominal pain, palpable cecal masses, intestinal obstruction, intussusception, and volvulus, have been observed beyond the neonatal period in patients with cystic fibrosis (CF). In a retrospective chart review of 63 patients with CF, we found evidence of one or more of these complications in 26 patients (41.3%). The incidence of intestinal complications was not related to overall disease severity, pulmonary exacerbations, history of meconium ileus at birth, or dose or type of pancreatic enzyme replacement. There was no change in the incidence of intestinal complications after patients switched to a pH-sensitive enteric-coated microsphere enzyme preparation.
在囊性纤维化（CF）患者的新生儿期之后，观察到了多种肠道并发症，包括便秘、腹痛、可触及的盲肠肿块、肠梗阻、肠套叠和肠扭转。在一项对63例CF患者的回顾性病历审查中，我们发现26例患者（41.3%）有这些并发症中的一种或多种。肠道并发症的发生率与总体疾病严重程度、肺部加重、出生时胎粪性肠梗阻病史或胰腺酶替代治疗的剂量或类型无关。患者改用pH敏感型肠溶微球酶制剂后，肠道并发症的发生率没有变化。
