Matthay R A, Ellis J H, Steele P P
Am Rev Respir Dis. 1978 May;117(5):871-7. doi: 10.1164/arrd.1978.117.5.871.
With a radionuclide technique, left ventricular ejection fraction and stroke volume index were measured in the basal state and after the stress of a methoxamine-induced increase in afterload in 10 men with severe chronic obstructive pulmonary disease. The resting mean left ventricular ejection fraction was normal in all 10 patients. After an acute increase in resistance to left ventricular ejection with methoxamine, the left ventricular ejection fraction and the stroke volume index did not decrease significantly, even in the presence of cor pulmonale in 5 patients. Mean pulmonary capillary wedge pressure was normal before, and did not change significantly after, methoxamine infusion. The data suggest that latent left ventricular dysfunction is not present in this group of patients with severe chronic obstructive pulmonary disease.
采用放射性核素技术，对10例重度慢性阻塞性肺疾病男性患者在基础状态下以及在甲氧明诱导后负荷增加的应激状态下测量左心室射血分数和每搏量指数。所有10例患者静息时的平均左心室射血分数均正常。在使用甲氧明使左心室射血阻力急性增加后，即使5例患者存在肺心病，左心室射血分数和每搏量指数也没有显著降低。甲氧明输注前平均肺毛细血管楔压正常，输注后也没有显著变化。数据表明，这组重度慢性阻塞性肺疾病患者不存在潜在的左心室功能障碍。
