Mellis C M, Kattan M, Keens T G, Levison H
Am Rev Respir Dis. 1978 May;117(5):911-5. doi: 10.1164/arrd.1978.117.5.911.
Fifty asthmatic children were tested with both a standardized treadmill exercise and a histamine inhalation on 2 separate days. Ninety per cent had a positive response to histamine, whereas 74 per cent had demonstrable exercise-induced bronchoconstriction. There was a close relationship between responsiveness to histamine and exercise, because all patients who responded to histamine had exercise-induced bronchoconstriction. Eight children (16 per cent) responded to histamine only. Although prechallenge pulmonary function has an effect on the incidence of exercise-induced bronchoconstriction, it does not appear to influence the responsiveness to histamine. Therefore, when provocation testing is being done for the purpose of diagnosing asthma, histamine is preferable to exercise.
五十名哮喘儿童在两个不同日期分别接受了标准化跑步机运动测试和组胺吸入测试。90%的儿童对组胺有阳性反应，而74%的儿童有明显的运动诱发支气管收缩。对组胺的反应性与运动之间存在密切关系，因为所有对组胺有反应的患者都有运动诱发支气管收缩。八名儿童（16%）仅对组胺有反应。尽管激发前肺功能对运动诱发支气管收缩的发生率有影响，但似乎并不影响对组胺的反应性。因此，当为诊断哮喘而进行激发试验时，组胺比运动更可取。
