运动诱发的支气管收缩作为支气管高反应性的一种表现：儿童发病机制的研究
Exercise-induced bronchoconstriction as an expression of bronchial hyperreactivity: a study of its mechanisms in children.
作者信息
Neijens H J, Wesselius T, Kerrebijn K F
出版信息
Thorax. 1981 Jul;36(7):517-22. doi: 10.1136/thx.36.7.517.
Abstract
The mechanism of exercise-induced bronchoconstriction (EIB) was studied by observing the protective effects of several aerosol agents in a double-blind, randomised trial. Exercise-induced bronchoconstriction was not affected by placebo, but was reduced by each agent used (p less than 0.001). Blocking the parasympathetic system had the weakest effect, while beta 2 adrenergic stimulation produced the strongest effect which was significantly different from the parasympatholytic (p less than 0.02). The effect of the mast cell stabilizer, sodium cromoglycate (SCG) was found to be intermediate. However in some patients SCG had a stronger effect than the beta 2 adrenergic agonist. A relationship was found between EIB and bronchial hyperreactivity induced by histamine (p less than 0.05).
摘要
在一项双盲随机试验中，通过观察几种气雾剂的保护作用，研究了运动诱发支气管收缩（EIB）的机制。运动诱发支气管收缩不受安慰剂影响，但每种使用的药物均可使其减轻（p<0.001）。阻断副交感神经系统的作用最弱，而β2肾上腺素能刺激产生的作用最强，且与抗副交感神经作用有显著差异（p<0.02）。发现肥大细胞稳定剂色甘酸钠（SCG）的作用居于中间。然而，在一些患者中，SCG的作用比β2肾上腺素能激动剂更强。发现EIB与组胺诱发的支气管高反应性之间存在关联（p<0.05）。
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Exercise-induced bronchoconstriction as an expression of bronchial hyperreactivity: a study of its mechanisms in children.运动诱发的支气管收缩作为支气管高反应性的一种表现：儿童发病机制的研究
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Comparative study of histamine and exercise challenges in asthmatic children.哮喘儿童组胺与运动激发试验的对比研究
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