Bernacki E J, Parsons G E, Sunderman F W
Ann Clin Lab Sci. 1978 May-Jun;8(3):190-4.
A case-control mortality study was performed at an aircraft engine factory to assess the possible association between exposure to nickel-containing compounds and death from lung cancer. Forty-two non-salaried male workers who died of lung cancer from 1966 to 1976 were identified from a chronological registry of death certificates that has been maintained by the company's medical department. Each of the decedents was matched with the next two non-salaried decedents in the registry who were of the same sex and comparable age (+/- 10 years), and who died of causes other than cancer. Without knowledge of the workmen's identities or causes of death, one of the authors classified the deceased workmen as exposed or non-exposed to nickel compounds during their employment. The proportion of workmen who died of lung cancer and were exposed to nickel (11/42) was found to be equal to the proportion of workmen who died of non-cancerous causes and were exposed to nickel (22/84). This study indicates that workers in an aircraft engine factory who were chronically exposed to low atmospheric concentrations of presumably weakly carcinogenic nickel compounds did not have any apparent increase in the relative risk of mortality from lung cancer prior to treatment.
在一家飞机发动机工厂进行了一项病例对照死亡率研究，以评估接触含镍化合物与肺癌死亡之间的可能关联。从该公司医疗部门保存的死亡证明按时间顺序登记册中，确定了1966年至1976年期间死于肺癌的42名非受薪男性工人。每名死者均与登记册中接下来两名同性且年龄相仿（±10岁）、死于癌症以外原因的非受薪死者进行匹配。在不了解工人身份和死亡原因的情况下，一位作者将已故工人在就业期间分为接触或未接触镍化合物两类。结果发现，死于肺癌且接触镍的工人比例（11/42）与死于非癌症原因且接触镍的工人比例（22/84）相等。这项研究表明，在一家飞机发动机工厂中，长期接触低大气浓度的可能弱致癌性镍化合物的工人，在治疗前肺癌死亡率的相对风险没有任何明显增加。
