清晨偏头痛。儿茶酚胺、色氨酸、葡萄糖和游离脂肪酸的夜间血浆水平以及睡眠脑电图。

Early morning migraine. Nocturnal plasma levels of catecholamines, tryptophan, glucose, and free fatty acids and sleep encephalographs.

作者信息

Hsu L K, Crisp A H, Kalucy R S, Koval J, Chen C N, Carruthers M, Zilkha K J

出版信息

Lancet. 1977 Feb 26;1(8009):447-51. doi: 10.1016/s0140-6736(77)91942-0.

DOI:10.1016/s0140-6736(77)91942-0

Abstract

Nocturnal plasma catecholamine, tryptophan, glucose, and free fatty acid levels have been measured in 19 subjects who regularly awoke from sleep with migraine. All-night polygraphic sleep recordings were also made. 13 subjects were studied on a second occasion allowing within-subject control as well as group comparison. Plasma total catecholamine and specifically plasma-noradrenaline levels were significantly higher in the three hours before the subjects awoke with migraine. No differences were found in plasma tryptophan, glucose, insulin, and free fatty acid levels in the migraine/no-migraine categories. Waking with migraine occurred significantly more often from rapid-eye movement (REM) sleep. There were no other differences in sleep pattern in the migraine/no-migraine categories.

摘要

已对19名经常在睡眠中因偏头痛醒来的受试者测量了夜间血浆儿茶酚胺、色氨酸、葡萄糖和游离脂肪酸水平。同时还进行了整夜的多导睡眠记录。13名受试者在第二次研究时进行了自身对照和组间比较。在受试者因偏头痛醒来前的三个小时内，血浆总儿茶酚胺，特别是血浆去甲肾上腺素水平显著升高。在偏头痛/无偏头痛组中，血浆色氨酸、葡萄糖、胰岛素和游离脂肪酸水平未发现差异。从快速眼动（REM）睡眠中醒来时出现偏头痛的情况明显更多。在偏头痛/无偏头痛组中，睡眠模式没有其他差异。