钒酸盐在体外对儿茶酚胺以及对小鼠和大鼠组织脂质过氧化的促氧化特性。
Prooxidant properties of vanadate in vitro on catecholamines and on lipid peroxidation by mouse and rat tissues.
作者信息
Donaldson J, LaBella F
出版信息
J Toxicol Environ Health. 1983 Jul;12(1):119-26. doi: 10.1080/15287398309530411.
PMID:6556257
Abstract
Vanadate (Na3VO4) in micromolar concentrations enhanced the in vitro formation of adrenochrome from epinephrine, and of aminochrome from dopamine. Lipid peroxides in various tissues of the mouse and rat, particularly brain, were increased. Products of both catecholamine oxidation and lipid peroxidation may be the basis of the cardiotoxic and neurotoxic effects of vanadium.
摘要
微摩尔浓度的钒酸盐（Na3VO4）增强了肾上腺素体外生成肾上腺色素以及多巴胺体外生成氨基色素的过程。小鼠和大鼠各种组织中的脂质过氧化物有所增加，尤其是大脑。儿茶酚胺氧化产物和脂质过氧化产物可能是钒产生心脏毒性和神经毒性作用的基础。
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