Hersey P, Morgan G, Stone D E, McCarthy W H, Milton G W
Lancet. 1977 Feb 26;1(8009):451-2. doi: 10.1016/s0140-6736(77)91943-2.
Examination of the case-records of women presenting to the Melanoma Unit at Sydney Hospital over the period 1961-71 has shown that women with pregnancies before the development of melanoma had a better survival-rate from melanoma than women without previous pregnancies. The known presence of fetal antigens on melanoma cells and immunisation against fetal antigens during pregnancy suggest an immunological explanation for these results. Exposure to fetal antigens during pregnancy may protect against the dissemination of melanoma cells bearing similar fetal antigens and thus increase the survival-rate. The incidence of melanoma in males and females was approximately equal, which suggests that immune responses to tumour-associated antigens may be more effective in preventing spread of tumours than in preventing their occurrence.
对1961年至1971年间到悉尼医院黑色素瘤科就诊的女性病例记录进行检查后发现，在黑色素瘤发生前怀孕的女性，其黑色素瘤的生存率高于未怀孕的女性。黑色素瘤细胞上已知存在胎儿抗原，以及孕期针对胎儿抗原进行免疫，这为这些结果提供了一种免疫学解释。孕期接触胎儿抗原可能会防止携带相似胎儿抗原的黑色素瘤细胞扩散，从而提高生存率。男性和女性黑色素瘤的发病率大致相等，这表明对肿瘤相关抗原的免疫反应在预防肿瘤扩散方面可能比对预防肿瘤发生更有效。
