Seddon J M, MacLaughlin D T, Albert D M, Gragoudas E S, Ference M
Br J Ophthalmol. 1982 Nov;66(11):695-704. doi: 10.1136/bjo.66.11.695.
We observed a young woman who showed growth of a choroidal melanoma over the course of 2 pregnancies, with subsequent enucleation of the eye. This is the first such documented case. In addition 4 other women with uveal malignant melanomas presented during pregnancy. This observed number of pregnancies (5) was greater than the expected number (2.1) among women of childbearing age who underwent enucleation with subsequent analysis in our pathology laboratory. However, this difference was not statistically significant. Further, more females 44 years of age or younger underwent enucleation for malignant melanoma than men of comparable age. Evaluation of these cases led us to propose that there is a subset of patients whose ocular melanomas are hormonally responsive. We therefore analysed uveal melanoma and choroidal tissue from 7 patients, including one of the pregnant women, for the presence of oestrogen receptors. No specific oestrogen binding was found. The possibilities that other hormones are involved or an immunological mechanism is operative are discussed.
我们观察到一名年轻女性，其脉络膜黑色素瘤在两次怀孕期间生长，随后眼球被摘除。这是首例有记录的此类病例。此外，还有4名患有葡萄膜恶性黑色素瘤的女性在怀孕期间就诊。我们病理实验室对接受眼球摘除并随后进行分析的育龄女性进行观察后发现，怀孕次数（5次）高于预期次数（2.1次）。然而，这种差异无统计学意义。此外，44岁及以下因恶性黑色素瘤接受眼球摘除的女性多于同龄男性。对这些病例的评估使我们提出，有一部分患者的眼部黑色素瘤对激素有反应。因此，我们分析了7名患者（包括一名孕妇）的葡萄膜黑色素瘤和脉络膜组织中雌激素受体的存在情况。未发现特异性雌激素结合。文中讨论了其他激素参与或免疫机制起作用的可能性。
