放射性标记抗人纤维蛋白抗体：一种新型血栓检测剂。

Radiolabelled anti-human fibrin antibody: a new thrombus-detecting agent.

作者信息

Bosnjaković V B, Janković B D, Horvat J, Cvoric J

出版信息

Lancet. 1977 Feb 26;1(8009):452-4. doi: 10.1016/s0140-6736(77)91944-4.

DOI:10.1016/s0140-6736(77)91944-4

Abstract

Rabbit anti-human fibrin globulin (A.F.G.) was labelled with iodine (131I) and used as a thrombus-detecting agent. 131I-A.F.G. labelled thrombi were displayed by means of a gamma scintillation camera. Normal subjects and patients with thrombophlebitis of legs, acute fibrin depositions other than thrombi, and chronic varicosities were examined. The 131I-A.F.G. technique detected both formed thrombi and those that were forming and could discriminate between acute thrombosis and chronic varicosities. Thrombophlebitis and extravascular fibrin depositions were best demonstrated between 24 and 27 hours of 131I-A.F.G. injection. Radiolabelled A.F.G. in normal veins and chronic varicosities was best displayed within 6 hours of injection.

摘要

兔抗人纤维蛋白球蛋白（A.F.G.）用碘（131I）标记，并用作血栓检测剂。用γ闪烁照相机显示131I-A.F.G.标记的血栓。对正常受试者以及患有腿部血栓性静脉炎、血栓以外的急性纤维蛋白沉积和慢性静脉曲张的患者进行了检查。131I-A.F.G.技术能检测到已形成的血栓和正在形成的血栓，并能区分急性血栓形成和慢性静脉曲张。在注射131I-A.F.G.后24至27小时之间，血栓性静脉炎和血管外纤维蛋白沉积显示得最为清晰。注射后6小时内，正常静脉和慢性静脉曲张中的放射性标记A.F.G.显示得最好。