Heumann A M, Stiffel C
Ann Immunol (Paris). 1978 Jan;129(1):13-27.
Mice genetically selected for high (HL) or low (LL) antibody responsiveness to sheep erythrocytes (SE) also differed in the immune response to other antigens. We have studied in details the non-specific effect of the selection on responsiveness to bovine seralbumin (BSA) that is an antigen non cross-reacting with SE. BSA has been used either heat-aggregated (H-BSA) or alum-precipitated (Al-BSA). The characteristics of the response to H-BSA and to SE both injected intravenously were similar in several aspects: ranges of interline difference in agglutinin response were equivalent; minimal immunogenic doses were lower in HL than in LL mice. As for SE, the use of an adjuvant (Al-BSA) increased the response of LL more than that of HL mice, so the interline difference decreased. The interline difference between minimal immunogenic doses was weaker with Al-BSA than with H-BSA (100 times and 10,000 times respectively). The threshold dose for induction of immunologic memory was lower in the HL than in LL mice. For Al-BSA this threshold dose was higher than the minimal immunogenice dose in both lines; for H-BSA it was higher (in HL) or equal (in LL) to the minimal immunogenic dose. The results of this article confirm that the selective breeding for SE responsiveness has modified the antibody response to BSA in a similar way. The group of genes controlling the level of antibody response are also responsible for the induction of immunological memory.
经基因选择对绵羊红细胞（SE）具有高（HL）或低（LL）抗体反应性的小鼠，对其他抗原的免疫反应也存在差异。我们详细研究了这种选择对牛血清白蛋白（BSA）反应性的非特异性影响，BSA是一种与SE无交叉反应的抗原。BSA采用热聚集（H-BSA）或明矾沉淀（Al-BSA）形式使用。静脉注射时，对H-BSA和SE的反应特征在几个方面相似：凝集素反应的品系间差异范围相当；HL小鼠的最小免疫原剂量低于LL小鼠。至于SE，使用佐剂（Al-BSA）时，LL小鼠的反应比HL小鼠增加得更多，因此品系间差异减小。Al-BSA的最小免疫原剂量之间的品系间差异比H-BSA弱（分别为100倍和10000倍）。HL小鼠诱导免疫记忆的阈值剂量低于LL小鼠。对于Al-BSA，该阈值剂量在两个品系中均高于最小免疫原剂量；对于H-BSA，它在HL中高于最小免疫原剂量，在LL中等于最小免疫原剂量。本文结果证实，针对SE反应性的选择性育种以类似方式改变了对BSA的抗体反应。控制抗体反应水平的基因群也负责免疫记忆的诱导。
