玉米赤霉烯酮和顺式、反式玉米赤霉烯醇的子宫促生长活性。
Uterotropic activity of cis and trans isomers of zearalenone and zearalenol.
作者信息
Mirocha C J, Pathre S V, Behrens J, Schauerhamer B
出版信息
Appl Environ Microbiol. 1978 May;35(5):986-7. doi: 10.1128/aem.35.5.986-987.1978.
Abstract
The cis and trans isomers of zearalenone [2,4-dihyroxy-6-(10-hydroxy-6-oxo-1-undecenyl)-benzoic acid mu-lactone] and zearalenol [2,4-dihydroxy-6-(6,10-dihydroxy-1-undecenyl)-benzoic acid mu-lactone] were tested for uterotropic activity in the white rat. The metabolites were administered through the oral route (per os) and by topical application to the freshly shaven skin on the back. cis-Zearalenone was significantly more active than trans when fed orally to the rats in the diet or when applied topically by skin application. However, the cis isomer of zearalenol was not significantly different than its trans isomer. trans-Zearalenone was less active than trans-zearalenol.
摘要
对玉米赤霉烯酮[2,4 - 二羟基 - 6 - (10 - 羟基 - 6 - 氧代 - 1 - 十一碳烯基) - 苯甲酸μ - 内酯]和顺式及反式玉米赤霉醇[2,4 - 二羟基 - 6 - (6,10 - 二羟基 - 1 - 十一碳烯基) - 苯甲酸μ - 内酯]在白鼠中进行了子宫促生长活性测试。这些代谢产物通过口服途径（经口）以及局部涂抹于背部刚剃毛的皮肤上给药。当经口喂食于饮食中的大鼠时或通过皮肤局部涂抹时，顺式玉米赤霉烯酮的活性显著高于反式。然而，玉米赤霉醇的顺式异构体与其反式异构体并无显著差异。反式玉米赤霉烯酮的活性低于反式玉米赤霉醇。
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