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玉米赤霉烯酮、α-玉米赤霉醇和β-玉米赤霉醇对猪、大鼠和鸡子宫及输卵管雌激素受体的相对结合亲和力测定：雌激素活性的一个指标

Measurement of the relative binding affinity of zearalenone, alpha-zearalenol and beta-zearalenol for uterine and oviduct estrogen receptors in swine, rats and chickens: an indicator of estrogenic potencies.

作者信息

Fitzpatrick D W, Picken C A, Murphy L C, Buhr M M

机构信息

Department of Foods and Nutrition, University of Manitoba, Winnipeg, Canada.

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1989;94(2):691-4. doi: 10.1016/0742-8413(89)90133-3.

DOI:10.1016/0742-8413(89)90133-3
PMID:2576797
Abstract
  1. The relative binding affinity of zearalenone, alpha-zearalenol, and beta-zearalenol for estrogen receptors was determined in the pig, rat and chicken. 2. Similar relative binding patterns were observed, with alpha-zearalenol exhibiting greater affinity than zearalenone and beta-zearalenol the least binding affinity in all species. 3. The relative binding affinity of alpha-zearalenol was greater in pig, than in rat and significantly greater than in chicken. 4. Interspecies differences in zearalenone sensitivity may be due to the binding affinity of alpha-zearalenol for estrogen receptors and differences in zearalenone metabolites formed.
摘要
  1. 测定了玉米赤霉烯酮、α-玉米赤霉醇和β-玉米赤霉醇对猪、大鼠和鸡雌激素受体的相对结合亲和力。2. 观察到相似的相对结合模式，在所有物种中，α-玉米赤霉醇表现出比玉米赤霉烯酮更高的亲和力，而β-玉米赤霉醇的结合亲和力最低。3. α-玉米赤霉醇在猪体内的相对结合亲和力高于大鼠，且显著高于鸡。4. 玉米赤霉烯酮敏感性的种间差异可能归因于α-玉米赤霉醇对雌激素受体的结合亲和力以及所形成的玉米赤霉烯酮代谢物的差异。

相似文献

1
Measurement of the relative binding affinity of zearalenone, alpha-zearalenol and beta-zearalenol for uterine and oviduct estrogen receptors in swine, rats and chickens: an indicator of estrogenic potencies.玉米赤霉烯酮、α-玉米赤霉醇和β-玉米赤霉醇对猪、大鼠和鸡子宫及输卵管雌激素受体的相对结合亲和力测定：雌激素活性的一个指标
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1989;94(2):691-4. doi: 10.1016/0742-8413(89)90133-3.
2
alpha-Zearalenol, a major hepatic metabolite in rats of zearalenone, an estrogenic mycotoxin of Fusarium species.α-玉米赤霉醇，是镰刀菌属雌激素性霉菌毒素玉米赤霉烯酮在大鼠体内的主要肝脏代谢产物。
J Biochem. 1981 Feb;89(2):563-71. doi: 10.1093/oxfordjournals.jbchem.a133232.
3
Transformation of zearalenone and zearalenol by rat erythrocytes.大鼠红细胞对玉米赤霉烯酮和玉米赤霉醇的转化作用。
Food Chem Toxicol. 1984 Nov;22(11):887-91. doi: 10.1016/0278-6915(84)90171-6.
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Plasma and urinary levels of zearalenone and alpha-zearalenol in a prepubertal gilt fed zearalenone.饲喂玉米赤霉烯酮的青春期前后备母猪血浆和尿液中玉米赤霉烯酮及α-玉米赤霉醇的水平
Acta Pharmacol Toxicol (Copenh). 1985 Mar;56(3):239-43. doi: 10.1111/j.1600-0773.1985.tb01282.x.
5
Zearalenone metabolism and excretion in the rat: effect of different doses.玉米赤霉烯酮在大鼠体内的代谢与排泄：不同剂量的影响
J Environ Sci Health B. 1988 Aug;23(4):343-54. doi: 10.1080/03601238809372610.
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Transmission of zearalenone and zearalenol into porcine milk.玉米赤霉烯酮和玉米赤霉醇向猪乳中的转移。
Acta Vet Acad Sci Hung. 1980;28(2):217-22.
7
Fish model for assessing the in vivo estrogenic potency of the mycotoxin zearalenone and its metabolites.用于评估霉菌毒素玉米赤霉烯酮及其代谢物体内雌激素活性的鱼类模型。
Sci Total Environ. 1999 Sep 15;236(1-3):153-61. doi: 10.1016/s0048-9697(99)00275-2.
8
Bioconversion of alpha-[14C]zearalenol and beta-[14C]zearalenol into [14C]zearalenone by Fusarium roseum 'Gibbosum'.粉红镰孢菌“ Gibbosum”将α-[14C]玉米赤霉烯醇和β-[14C]玉米赤霉烯醇生物转化为[14C]玉米赤霉酮。
Appl Environ Microbiol. 1984 Jun;47(6):1206-9. doi: 10.1128/aem.47.6.1206-1209.1984.
9
Species differences in zearalenone-reducing activity in subcellular fractions of liver from female domestic animals.雌性家畜肝脏亚细胞组分中玉米赤霉烯酮还原活性的物种差异。
Acta Pharmacol Toxicol (Copenh). 1983 Apr;52(4):287-91. doi: 10.1111/j.1600-0773.1983.tb01102.x.
10
Biotransformation of zearalenone to zearalenol by Candida tropicalis.热带假丝酵母将玉米赤霉烯酮转化为玉米赤霉醇。
Acta Vet Acad Sci Hung. 1980;28(2):159-66.

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