Merin G, Eimerl D, Raz S, Tzivoni D, Gotsman M S
Ann Thorac Surg. 1978 Jun;25(6):536-40. doi: 10.1016/s0003-4975(10)63604-1.
The left anterior descending or left circumflex coronary artery was cannulated selectively in 10 dogs. Methylprednisolone, 1 mg per kilogram of body weight, was injected into the artery and the cannula was withdrawn. The animals were then subjected to hemorrhagic shock for 90 minutes. Retransfusion to prestudy blood pressure was then accomplished. The electrocardiogram, arterial blood pressure, contractile force, and first derivative of contractile force were recorded continously both from the areas that were pretreated and those that were not, the controls. Contractile force in the control area was reduced to 32 +/- 3.2% of the preshock period after 90 minutes of shock, whereas in the pretreated area it was twice as high at the same time. Ten minutes after transfusion, the contractile force of the pretreated area exceeded the preshock level, whereas the recovery of contractile force in the control area reached only 70% of the preshock level. This study shows that intracoronary infusion of methylpredisolone can afford myocardial protection in hemorrhagic shock to a significant degree.
对10只犬选择性地插管至左前降支或左旋冠状动脉。将每千克体重1毫克的甲基泼尼松龙注入动脉，然后拔出插管。接着使动物遭受90分钟的失血性休克。随后将血压恢复至研究前水平。连续记录预处理区域和未预处理区域（即对照区域）的心电图、动脉血压、收缩力以及收缩力的一阶导数。休克90分钟后，对照区域的收缩力降至休克前水平的32±3.2%，而在预处理区域，此时收缩力是对照区域的两倍。输血10分钟后，预处理区域的收缩力超过休克前水平，而对照区域收缩力的恢复仅达到休克前水平的70%。本研究表明，冠状动脉内输注甲基泼尼松龙可在很大程度上为失血性休克中的心肌提供保护。
