Merin G, Rosenhack S, Gotsman M S
Basic Res Cardiol. 1978 Jan-Feb;73(1):27-33. doi: 10.1007/BF01914653.
The left anterior descending or left circumflex coronary artery was cannulated in ten dogs. 4 mg/kg hydrocortisone were slowly infused and the cannula was withdrawn. The dogs were then subjected to hemorrhagic shock for 90 minutes followed by retransfusion. The contractile force (CF) and its first derivative (df/dt) were measured in the pretreated (infused) area and in a control (non-perfused) area of the left ventricle. During the shock period, CF and df/dt in the non-pretreated area showed a 50% reduction in comparison to the pre-shock level, whereas the contractile force in the area that had been pretreated with hydrocortisone did not change when compared to the pre-shock period. This study shows that myocardial depression secondary to hemorrhagic shock can be effectively prevented by pretreatment with hydrocortisone.
在十只狗身上，对左前降支或左旋冠状动脉进行插管。缓慢输注4毫克/千克氢化可的松，然后拔出插管。接着让这些狗经历90分钟的失血性休克，随后进行再输血。在左心室的预处理（输注）区域和对照（未灌注）区域测量收缩力（CF）及其一阶导数（df/dt）。在休克期，未预处理区域的CF和df/dt与休克前水平相比降低了50%，而与休克前时期相比，用氢化可的松预处理的区域的收缩力没有变化。这项研究表明，失血性休克继发的心肌抑制可以通过氢化可的松预处理得到有效预防。
