Dewald G, Lange C E, Schmeel E, Kreysel H W
Arch Dermatol Res. 1983;275(5):301-4. doi: 10.1007/BF00417201.
Starting from the known association between psoriasis and several HLA antigens and from the fact that the HLA chromosomal region contains the structural genes for at least three complement components, the authors have looked for an association between psoriasis and allotypes of C2 and BF. C2 and BF polymorphism were examined in 230 psoriatic patients. Two rare complement genes were found to be significantly increased when compared with controls: the frequency of the C22 gene was 0.061 among patients and 0.035 among controls (P less than 0.05); for BFSO7, the frequencies were 0.0304 in patients and 0.0092 in controls (P less than 0.0005). The BFF gene frequency, however, was significantly decreased among patients: 0.1196 vs. 0.1743 (P less than 0.01). The relative risks were 1.79 for the C2 2, 3.44 for the BF SO7, and 0.6 for the BF F gene product. From previous studies, it is known that these three complement alleles (C22, BFSO7, BFF) are in linkage disequilibrium with HLA alleles that have also been found increased or decreased, respectively, in psoriasis.
基于银屑病与多种HLA抗原之间已知的关联，以及HLA染色体区域包含至少三种补体成分的结构基因这一事实，作者们探寻了银屑病与C2和BF同种异型之间的关联。对230例银屑病患者的C2和BF多态性进行了检测。与对照组相比，发现两种罕见的补体基因显著增加：患者中C22基因的频率为0.061，对照组为0.035（P小于0.05）；对于BFSO7，患者中的频率为0.0304，对照组为0.0092（P小于0.0005）。然而，患者中BFF基因频率显著降低：分别为0.1196和0.1743（P小于0.01）。C22的相对风险为1.79，BFSO7为3.44，BFF基因产物为0.6。从先前的研究可知，这三种补体等位基因（C22、BFSO7、BF*F）与在银屑病中也分别发现增加或减少的HLA等位基因处于连锁不平衡状态。
