Etzrodt A, Jung H, Schweissfurth C, Tolxdorff T, Lamberti G
Geburtshilfe Frauenheilkd. 1983 Dec;43(12):726-31. doi: 10.1055/s-2008-1036742.
In 337 patients with primary cancer of the breast, the oestrogen and progesterone receptor concentration was correlated to the metastasis of axillary lymph nodes taking into account the age of the patients and the size of the primary tumour. The frequency of axillary lymph node involvement increases significantly with size, although not quite steadily but rather stepwise within the T classification. Whereas the tumour diameter influences the receptor status only slightly, the age of the patients plays a major rôle in the oestrogen receptor concentration. In the age group up to 50 years the oestrogen receptor concentration is significantly lower than in the age group over 50 years. There is no comparable influence of age on progesterone receptor concentration. With all 337 breast cancers, no difference in axillary lymph node metastasis is found either between oestrogen receptor positive and oestrogen receptor negative cancers, or between progesterone receptor positive and progesterone receptor negative cancers. In the age group up to 50 years, if looked upon separately, the oestrogen receptor positive cancers do show significantly more often an axillary lymph node involvement, than do oestrogen receptor negative cancers. As this difference exists in the age group up to 50 years only, it is assumed that endogenous oestradiol favours the axillary spread in oestrogen receptor positive cancers. With oestrogen receptor negative cancers the axillary lymph node involvement increases from the younger to the older age group, explaining why in unselected series the oestrogen receptor negative cancers show a more unfavourable course.
在337例原发性乳腺癌患者中，考虑到患者年龄和原发肿瘤大小，对雌激素和孕激素受体浓度与腋窝淋巴结转移的相关性进行了研究。腋窝淋巴结受累的频率随肿瘤大小显著增加，尽管在T分类中并非完全呈稳定上升，而是呈阶梯式上升。肿瘤直径对受体状态的影响较小，而患者年龄对雌激素受体浓度起主要作用。在50岁及以下年龄组中，雌激素受体浓度显著低于50岁以上年龄组。年龄对孕激素受体浓度没有类似影响。在所有337例乳腺癌中，雌激素受体阳性和阴性癌症之间，以及孕激素受体阳性和阴性癌症之间，腋窝淋巴结转移均无差异。在50岁及以下年龄组中，单独来看，雌激素受体阳性癌症腋窝淋巴结受累的发生率显著高于雌激素受体阴性癌症。由于这种差异仅存在于50岁及以下年龄组，因此推测内源性雌二醇有利于雌激素受体阳性癌症的腋窝扩散。对于雌激素受体阴性癌症，腋窝淋巴结受累从年轻年龄组到老年年龄组增加，这解释了为什么在未选择的系列中，雌激素受体阴性癌症显示出更不利的病程。
