Toyama M, Reis R L
J Thorac Cardiovasc Surg. 1975 Sep;70(3):458-65.
The effects of hydrocortisone on left ventricular force-velocity relations, systolic length-tension curves, and diastolic pressure-volume curves (compliance) were determined before and 30 and 60 minutes after a 1 hour period of normothermic ischemic cardioplegia. Five dogs were given no hydrocortisone, 5 dogs 150 mg. per kilogram of hydrocortisone immediately after aortic unclamping, and 5 dogs 150 mg. per kilogram of hydrocortisone 20 minutes before clamping. Thirty minutes after unclamping, there was a 45 per cent decrease in contractility (p less than 0.005). At 60 minutes, there was a significant improvement (p less than 0.025), although a 32 per cent depression persisted. There were no differences among the three groups (p less than 0.05). Dogs not given hydrocortisone before clamping, compliance decreased 18 per cent (p less than 0.05), and in those given hydrocortisone immediately after unclamping, compliance decreased 28 per cent (p less than 0.025). The decreases in compliance in the hydrocortisone-treated dogs were significantly less (p less than 0.05) than the decreases observed in the dogs not given hydrocortisone.
在进行1小时常温缺血性心脏停搏之前、之后30分钟和60分钟，测定氢化可的松对左心室力-速度关系、收缩期长度-张力曲线以及舒张压-容积曲线（顺应性）的影响。5只狗未给予氢化可的松，5只狗在主动脉夹闭后立即给予每千克150毫克氢化可的松，5只狗在夹闭前20分钟给予每千克150毫克氢化可的松。夹闭解除后30分钟，收缩力下降45%（p<0.005）。60分钟时，虽仍有32%的抑制，但有显著改善（p<0.025）。三组之间无差异（p<0.05）。夹闭前未给予氢化可的松的狗，顺应性下降18%（p<0.05），夹闭解除后立即给予氢化可的松的狗，顺应性下降28%（p<0.025）。接受氢化可的松治疗的狗的顺应性下降明显小于未给予氢化可的松的狗（p<0.05）。
