Ritch A E, George C F, Castleden C M, Hall M R
Lancet. 1977 Mar 5;1(8010):504-6. doi: 10.1016/s0140-6736(77)91370-8.
Response to oral and intramuscular emepronium bromide was assessed cystometrically in nine patients with urinary incontinence caused by an uninhibited bladder. Oral therapy had no effect, whereas intramuscular administration increased bladder capacity and significantly delayed the onset of bladder spasm and the desire to void. Plasma-propranolol response was delayed and concentrations were reduced after an oral 40 mg dose of propranolol in 3 patients who had received oral emepronium bromide. These results indicate that although oral emepronium bromide had some anticholinergic effect--i.e., in reducing gastrointestinal motility--absorption of an oral dose was not sufficient for the bladder to be affected.
对9例因膀胱无抑制性收缩导致尿失禁的患者，采用膀胱测压法评估口服和肌内注射溴美喷铵的反应。口服治疗无效，而肌内注射可增加膀胱容量，并显著延迟膀胱痉挛发作和排尿欲望。3例口服过溴美喷铵的患者，口服40mg普萘洛尔后，血浆普萘洛尔反应延迟，浓度降低。这些结果表明，尽管口服溴美喷铵有一定的抗胆碱能作用，即减少胃肠蠕动，但口服剂量的吸收不足以影响膀胱。
