一种用于研究乳糜泻发病机制的新型实验系统。
A new experimental system for the study of the pathogenesis of coeliac disease.
作者信息
Hudson D A, Anderson C M
出版信息
Lancet. 1977 Mar 5;1(8010):511-2. doi: 10.1016/s0140-6736(77)91373-3.
PMID:65611
Abstract
A method is described for the differential removal of epithelial cells from human intestinal-tissue specimens. Epithelial cells can be freed of contaminating cells such as erythrocytes, and on the basis of microscopic appearance, dye exclusion tests, and short-term survival in defined media are viable. The experimental system can be used to investigate the differential cytotoxic effects,if any, of specific gluten components upon cells from normal subjects and coeliac patients.
摘要
本文描述了一种从人肠道组织标本中选择性去除上皮细胞的方法。上皮细胞可去除如红细胞等污染细胞，并且根据显微镜下外观、染料排斥试验以及在特定培养基中的短期存活情况，这些上皮细胞是有活力的。该实验系统可用于研究特定谷蛋白成分对正常受试者和乳糜泻患者细胞是否存在差异细胞毒性作用。
Zotero 插件