酰基激肽释放酶；一种激肽释放酶的递送系统。
Acyl-kallikrein; a delivery system for the kinin-liberating enzyme.
作者信息
Markwardt F, Stürzebecher J, Müller H
出版信息
Experientia. 1984 Apr 15;40(4):373-4. doi: 10.1007/BF01952559.
PMID:6562018
Abstract
Glandular kallikrein can be temporarily acylated at the active centre by 4-amidinophenyl benzoates. The time course of reactivation depends on the nature of the acyl group introduced. Benzoyl kallikrein was used as a delivery system for kallikrein in vivo. In rabbits, bolus injection of the acylated enzyme caused a long-lasting drop in blood pressure due to sustained kinin liberation.
摘要
腺激肽释放酶可在活性中心被4-脒基苯甲酸酯暂时酰化。再活化的时间进程取决于引入的酰基的性质。苯甲酰激肽释放酶被用作激肽释放酶在体内的递送系统。在兔子中，大剂量注射酰化酶会因持续释放激肽而导致血压长期下降。
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