δ1-四氢大麻酚的支气管扩张作用。
Bronchodilator effect of delta1-tetrahydrocannabinol.
作者信息
Hartley J P, Nogrady S G, Seaton A
出版信息
Br J Clin Pharmacol. 1978 Jun;5(6):523-5. doi: 10.1111/j.1365-2125.1978.tb01667.x.
Abstract
1 delta1-trans-tetrahydrocannabinol, (delta1-THC) produces bronchodilatation in asthmatic patients. 2 Administered in 62 microliter metered volumes containing 50--200 microgram by inhalation from an aerosol device to patients judged to be in a steady state, it increased peak expiratory flow rate (PEFR) and forced expiratory volume in 1 second (FEV1). 3 The rate of onset, magnitude, and duration of the bronchodilator effect was dose related.
摘要
- δ1-反式-四氢大麻酚（δ1-THC）可使哮喘患者支气管扩张。2. 以62微升定量体积给药，其中含有50 - 200微克，通过气雾剂装置吸入给判定处于稳定状态的患者，它可增加呼气峰值流速（PEFR）和1秒用力呼气量（FEV1）。3. 支气管扩张作用的起效速率、程度和持续时间与剂量相关。
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