Collie M H, Sweet C, Cavanagh D, Smith H
Br J Exp Pathol. 1978 Apr;59(2):190-5.
Inoculation of influenza virus into pregnant ferrets during the late gestational period was investigated. Foetal resorption followed intracardial inoculation of a large dose of influenza virus (10(9.4) EBID50) and a 100-fold lower dose caused lower litter sizes at birth. The possible role of fever in foetal resorptions was largely discounted by 2 observations: a non-pyrexic dose inoculated intracardially into the pregnant ferret still had detrimental effects on foetal viability; influenza virus inoculated intranasally caused a pyrexia but did not affect the progeny. The potential of the ferret as a model for studying the possible adverse effects of influenza during pregnancy is discussed.
研究了在妊娠后期将流感病毒接种到怀孕雪貂体内的情况。在心脏内接种大剂量流感病毒(10(9.4) EBID50)后出现胎儿吸收,而剂量降低100倍则导致出生时窝仔数减少。两项观察结果很大程度上排除了发热在胎儿吸收中的可能作用:经心脏内接种到怀孕雪貂体内的无热剂量仍对胎儿活力有不利影响;经鼻接种流感病毒会引起发热,但不影响后代。讨论了雪貂作为研究孕期流感可能产生的不良影响的模型的潜力。