Goeschen K, Jäger A, Saling E
Geburtshilfe Frauenheilkd. 1984 Jun;44(6):351-5. doi: 10.1055/s-2008-1036675.
Hypotension during pregnancy must be taken seriously. This complication is definitely serious enough to merit treatment. However, examinations have been lacking so far proving the advantages or possible risks of antihypotensive therapy. A short while ago the authors reported on favourable results obtained with dihydroergotamin (DHE) in hypotensive patients. It was the aim of the present study to test this finding, which had been obtained with a relatively small group of patients, by employing a large group. The evaluation was based on the statistical data from 400 hypotensive pregnant women who had delivered during the time between 1.1. 1982 and 31.8. 1983 in the obstetrical department of the Berlin-Neukölln Hospital Pregnant women were considered to be hypotensive if they had appeared for examination at least three times up to the 28th week of pregnancy with a maximum systolic blood pressure of less than or equal to 110 mmHg and diastolic pressure of less than or equal to 60 mm Hg. In relation to the total number of births of 4763, the proportion of hypotensives was 8.4%. 204 (4.3%) hypotensive women were subjected to DHE treatment; 156 of these took regularly 2 X 2.5 mg DETMS retard, whereas compliance was irregular with the remaining 50 patients. 196 (4.1%) refused treatment. The fact that the percentage of women willing to undergo treatment was relatively low (39%) is attributed partly to pregnant women being afraid of taking drugs, and partly to the attitude adopted by gynaecologists who are often hardly convinced that hypotension is a grave sign.(ABSTRACT TRUNCATED AT 250 WORDS)
孕期低血压必须引起重视。这种并发症确实严重到值得治疗。然而,迄今为止缺乏相关检查来证明抗低血压治疗的益处或潜在风险。不久前,作者报道了二氢麦角胺(DHE)治疗低血压患者取得的良好效果。本研究的目的是通过扩大样本量来验证这一在相对少数患者中获得的发现。评估基于1982年1月1日至1983年8月31日期间在柏林-新克尔恩医院产科分娩的400名低血压孕妇的统计数据。如果孕妇在怀孕28周前至少接受过三次检查,且收缩压最高不超过110 mmHg,舒张压最高不超过60 mmHg,则被视为低血压患者。相对于4763例总出生数,低血压患者的比例为8.4%。204名(4.3%)低血压女性接受了DHE治疗;其中156人定期服用2×2.5 mg缓释二氢麦角胺,其余50名患者服药依从性不佳。196名(4.1%)患者拒绝治疗。愿意接受治疗的女性比例相对较低(39%),部分原因是孕妇害怕服药,部分原因是妇科医生的态度,他们往往不太相信低血压是一个严重迹象。(摘要截选至250字)