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移植手术后乙肝的再激活。

Reactivation of hepatitis b after transplantation operations.

作者信息

Nagington J

出版信息

Lancet. 1977 Mar 12;1(8011):558-60. doi: 10.1016/s0140-6736(77)91995-x.

DOI:10.1016/s0140-6736(77)91995-x
PMID:65656
Abstract

Surveillance of the staff and patients at the Cambridge Transplant and Dialysis Unit for hepatitis-B infection since 1968 has revealed the onset of antigenaemia in 6 patients in eight years. When the first serum of each patient admitted was examined for anti-HBc antibody, 23 of 380 (6-1%) patients were found positive. Since the presence of anti-HBc is taken to be evidence of previous infection, the occurence of antigenaemia in 3 of the positives when they were immunosuppressed after transplantation is believed to be due to reactivation of latent infection. This is a new factor to be considered in the control of hepatitis B after transplantation;

摘要

自1968年以来,对剑桥移植与透析科的工作人员和患者进行的乙型肝炎感染监测显示,八年间有6名患者出现抗原血症。在对每位入院患者的首份血清进行抗-HBc抗体检测时,发现380名患者中有23名(6.1%)呈阳性。由于抗-HBc的存在被视为既往感染的证据,因此据信3名阳性患者在移植后免疫抑制期间出现抗原血症是由于潜伏感染的重新激活。这是移植后控制乙型肝炎时需要考虑的一个新因素;

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