Li Volti S, Pizzarelli G, Galimberti M, Di Gregorio F, Romeo M A, Lucarelli G, Russo G
I Istituto di Clinica Pediatrica, Università di Catania, Italy.
Infection. 1998 Jan-Feb;26(1):58-60. doi: 10.1007/BF02768759.
The case of a young man affected by homozygous beta-thalassemia is reported who had serologic findings of a prior HBV infection and who presented with clinical and biochemical acute HBV infection probably caused by HBV reactivation after allogeneic bone marrow transplantation. The patient's clinical history suggests that HBV can persist without serological findings of HBsAg and HBV-DNA in persons previously infected by HBV and that HBV reactivation can occur 2 years after allogeneic bone marrow transplantation, as a result of immunosuppressive therapy or an HCV activation.
报告了一例患有纯合子β地中海贫血的年轻男性病例，该患者有既往HBV感染的血清学表现，且在异基因骨髓移植后出现了可能由HBV再激活引起的临床和生化急性HBV感染。患者的临床病史表明，HBV可在既往感染HBV的人群中持续存在而无HBsAg和HBV-DNA的血清学表现，并且异基因骨髓移植2年后，由于免疫抑制治疗或HCV激活，可能发生HBV再激活。
