Taranova N P
Biull Eksp Biol Med. 1978 Apr;85(4):427-9.
A severe form of chronic intoxication was caused in guinea pigs by a single intracutaneous inoculation of triorthocresyl phosphate (TOCP); the intensity of acetate-2(14)C incorporation into the brain stem and spinal cord phospholipids and cholesterol was investigated in vivo. In paralytic stage of the disease incorporation of 14C into phospholipids and cholesterol was found to be markedly depressed; the inhibition of the synthesis of these lipids was observed not only in the most vulnerable lumbo-sacral region of the spinal cord, but also in the brain stem. This finding is in favour of the systemic character of lipid metabolism disorder in the central nervous system and indicates alteration of oligodendrocyte metabolism caused by TOCP.
通过向豚鼠皮内单次接种磷酸三甲苯酯（TOCP）引发了一种严重的慢性中毒形式；在体内研究了乙酸盐 - 2(¹⁴)C掺入脑干和脊髓磷脂及胆固醇的强度。在疾病的麻痹阶段，发现¹⁴C掺入磷脂和胆固醇的量明显降低；不仅在脊髓最易受损的腰骶部区域，而且在脑干中都观察到了这些脂质合成的抑制。这一发现支持中枢神经系统脂质代谢紊乱的全身性特征，并表明TOCP导致少突胶质细胞代谢改变。
