Taranova N P, Katsnel'son I P
Vopr Med Khim. 1976 Jan-Feb;22(1):108-12.
In rabbits the acute form of experimental allergic encephalomyelitis was caused by inoculation of emulsion of homologous myelin from spinal cord with Freund's adjuvant. In terminal paralytic period of the disease the animals were subcutaneously administered with 2-14C-acetate and a dose 50 micronCi per 100 g of body weight 2 hrs before death. From lumbar and stem sections of the central nervous system purified fractions of cerebrosides and gangliosides were isolated and their specific radioactivity was determined. The intensity of the cerebrosides synthesis was found to be distinctly decreased not only in the more impaired lumbar region but also in the stem section of the central nervous system, where the centers of demyelinization were not observed. The intensity of the gangliosides synthesis was also markedly decreased, in spite of that their content was not altered in the central nervous system under experimental allergic encephalomyelitis.
在兔子身上，实验性过敏性脑脊髓炎的急性形式是通过将来自脊髓的同源髓磷脂乳液与弗氏佐剂接种而引发的。在疾病的终末期麻痹阶段，在动物死亡前2小时皮下注射2-¹⁴C-醋酸盐，剂量为每100克体重50微居里。从中枢神经系统的腰段和脑干部分分离出脑苷脂和神经节苷脂的纯化部分，并测定它们的比放射性。结果发现，不仅在受损更严重的腰段，而且在中枢神经系统的脑干部分（未观察到脱髓鞘中心），脑苷脂的合成强度都明显降低。神经节苷脂的合成强度也显著降低，尽管在实验性过敏性脑脊髓炎的情况下，它们在中枢神经系统中的含量没有改变。
