[Effect of the phosphonic acid derivatives ethephon and trichlorphon on the incorporation in vivo of (14C)-acetate into cholesterol and other lipids in rats].

The effect of the phosphonic acid derivatives Ethephon and Trichlorphon on the incorporation of 14C-labelled acetate into lipids especially cholesterol was investigated. Adult Wistar rats were fed for 7 days diets containing 50 and 500 ppm, respectively, of the phosphonic acid derivatives. Both compounds caused a significant increase of the 14C-activity in lipids of serum, liver, heart, and brain. The effect of Ethephon was significantly more intense than that of Trichlorphon. The important finding was the Ethephon-induced increase of the [14C]-acetate incorporation into cholesterol which continued across all the tissues studied.