Vertiev Iu V, Ezepchuk Iu V
Biull Eksp Biol Med. 1978 May;85(5):549-51.
Adsorption of diphtheria toxin on immobilized cell membrane preparations in the presence of gangliosides was studied. A mixture of gangliosides completely inhibited the adsorption of diphtheria toxin on the cell membranes, both sensitive (HeLa cells, macrophages) and resistant (L-cells) to its action. Neuraminidase-treated gangliosides were less effective. Immobilized gangliosides adsorbed diphtheria toxin effectively in the presence of a protective colloid and detergent triton X-100. The results obtained suggest gangliosides to be diphtheria toxin receptors.
研究了在神经节苷脂存在下白喉毒素在固定化细胞膜制剂上的吸附情况。神经节苷脂混合物完全抑制了白喉毒素在对其作用敏感（HeLa细胞、巨噬细胞）和抗性（L细胞）的细胞膜上的吸附。经神经氨酸酶处理的神经节苷脂效果较差。在保护性胶体和去污剂曲拉通X-100存在下，固定化神经节苷脂能有效吸附白喉毒素。所得结果表明神经节苷脂是白喉毒素受体。
