[神经生长因子对白喉毒素作用下器官型培养感觉神经元的保护作用]
[The protective effect of the nerve growth factor on sensory neurons in organotypic culture under the action of diphtheria toxin].
作者信息
Romaniuk A V, Davydovskaia M V, Sorokina M N, Chalisova N I, Liudyno M I
出版信息
Tsitologiia. 1995;37(3):216-9.
PMID:8553459
Abstract
Diphtheria toxin (1.10(-1) - 1.10(-6) Lf/ml) was found to inhibit neurite extension in chick embryo dorsal root ganglia in vitro. If the nerve growth factor (60 ng/ml) was added with the toxin to culture media, the effect of diphtheria toxin was seen to decrease and the neurite outgrowth was compared with control. Protective effect of nerve growth factor estimated by the influence of diphtheria toxin may be used for new principles of diphtheria treatment.
摘要
已发现白喉毒素（1.10(-1) - 1.10(-6)Lf/ml）在体外可抑制鸡胚背根神经节的神经突延伸。若将神经生长因子（60 ng/ml）与毒素一同添加到培养基中，可见白喉毒素的作用减弱，且将神经突生长情况与对照组进行了比较。通过白喉毒素的影响来评估神经生长因子的保护作用，这可用于白喉治疗的新原则。
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