Schreml W, Bargon G, Anger B, Kubanek B, Heimpel H
Blut. 1978 Jun 20;36(6):353-6. doi: 10.1007/BF01000593.
In two patients with acute leukaemia, the development of progressive interstitial pulmonary fibrosis was observed following chemotherapy with BCNU, Cytoxan and Ara-C. The x-ray changes were accompanied by restrictive changes of pulmonary function and, later on, by severe hypoxia. Serologic tests did not reveal infection with cytomegaly virus or mycoplasma pneumoniae. These findings, together with reports in the literature, suggest a toxic effect of BCNU on the lung. The combination with Cyclophosphamide may contribute to this toxic reaction.
在两名急性白血病患者中，观察到在接受卡氮芥、环磷酰胺和阿糖胞苷化疗后出现进行性间质性肺纤维化。X线改变伴有肺功能的限制性改变，随后出现严重缺氧。血清学检查未发现巨细胞病毒或肺炎支原体感染。这些发现以及文献报道提示卡氮芥对肺有毒性作用。与环磷酰胺联合使用可能会导致这种毒性反应。
