Melato M, Tuveri G
Cancer. 1980 Mar 15;45(6):1311-4. doi: 10.1002/1097-0142(19800315)45:6<1311::aid-cncr2820450607>3.0.co;2-u.
Two women, 65 and 55 years old, with metastatic malignant melanoma, were treated with low doses of BCNU for a short period (six and three months, total dose 2500 and 2000 mg). Both patients developed pulmonary fibrosis, which was visible in postmortem examination. In the first woman, lesion development was so widespread as to be considered responsible for death. Because chest x-ray before treatment was not abnormal, we consider BCNU capable of inducing the lesion.
两名分别为65岁和55岁的患有转移性恶性黑色素瘤的女性，接受了短疗程低剂量卡莫司汀（BCNU）治疗（分别为6个月和3个月，总剂量2500毫克和2000毫克）。两名患者均出现了肺纤维化，尸检可见。在第一名女性患者中，病变发展极为广泛，被认为是导致死亡的原因。由于治疗前胸部X光检查并无异常，我们认为卡莫司汀能够诱发该病变。
