铅中毒大鼠的肝脏药物代谢和血红素生物合成
Hepatic drug metabolism and haem biosynthesis in lead-poisoned rats.
作者信息
Goldberg A, Meredith P A, Miller S, Moore M R, Thompson G G
出版信息
Br J Pharmacol. 1978 Apr;62(4):529-36. doi: 10.1111/j.1476-5381.1978.tb07757.x.
Abstract
1 Pretreatment of rats with intraperitoneal injections of lead was shown to result in a depression of the microsomal mixed function oxidase system, as assessed by a decrease in hepatic microsomal P-450 and b5 content and by a decrease in the activity of the enzymes aniline hydroxylase and aminopyrine demethylase. Lead had a more marked effect on cytochrome P-450 than b5. 2 The activity of the rate-limiting enzyme of haem biosynthesis, delta-aminolaevulinic acid synthase, was inversely correlated with the microsomal cytochrome P-450 content. 3 The activity of the haem biosynthetic enzymes delta-aminolaevulinic acid dehydratase, coproporphyrinogen oxidase and ferrochelatase were decreased by increasing lead pretreatment. 4 The activity of the haem catabolic enzyme, haem oxygenase, was increased by lead pretreatment.
摘要
- 腹腔注射铅对大鼠进行预处理后，微粒体混合功能氧化酶系统出现抑制，这可通过肝脏微粒体P - 450和b5含量的降低以及苯胺羟化酶和氨基比林脱甲基酶活性的降低来评估。铅对细胞色素P - 450的影响比对b5的影响更显著。2. 血红素生物合成限速酶δ-氨基-γ-酮戊酸合酶的活性与微粒体细胞色素P - 450含量呈负相关。3. 随着铅预处理剂量增加，血红素生物合成酶δ-氨基-γ-酮戊酸脱水酶、粪卟啉原氧化酶和亚铁螯合酶的活性降低。4. 铅预处理可使血红素分解代谢酶血红素加氧酶的活性增加。
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