Neuman I, Inbar O, Creter D
Ann Allergy. 1984 Oct;53(4):351-4.
Seventeen asthmatic children, nine with and eight without exercise-induced asthma (EIA), and nine control non-asthmatic children were studied in an attempt to discern possible associations between the activity of the kinin system and EIA. Pulmonary function tests and clinical check-up were performed before and after 6 min of free-range running. Concomitant blood tests revealed a consistent elevation of the kallikrein levels following the exercise challenge in all experimental groups. However, only in the EIA positive group did this elevation exceed the normal laboratory range (16 +/- 7.0 mu/ml). Prekallikrein levels both before and after exercise did not exceed in any group the normal laboratory values. The findings thus suggest that provocation of EIA is associated with a certain threshold of kallikrein level below which no such symptoms are observed. EIA may be triggered only when kallikrein levels are in excess.
对17名哮喘儿童（其中9名有运动诱发性哮喘[EIA]，8名无运动诱发性哮喘）和9名对照非哮喘儿童进行了研究，以试图找出激肽系统活性与运动诱发性哮喘之间可能存在的关联。在自由跑步6分钟前后进行了肺功能测试和临床检查。同时进行的血液检测显示，在所有实验组中，运动激发后激肽释放酶水平持续升高。然而，只有在运动诱发性哮喘阳性组中，这种升高超过了实验室正常范围（16±7.0μg/ml）。运动前后的前激肽释放酶水平在任何组中均未超过实验室正常值。因此，研究结果表明，运动诱发性哮喘的激发与激肽释放酶水平的某个阈值相关，低于该阈值则未观察到此类症状。只有当激肽释放酶水平过高时，才可能引发运动诱发性哮喘。
