Wasserman G A, Llewellyn M W, Ramsay C A, Haberman H F
Can Med Assoc J. 1978 Jun 10;118(11):1379-83.
Between May 1976 and September 1977, 51 patients with severe psoriasis were treated with orally administered 8-methoxypsoralen followed by exposure to high-intensity long-wavelength ultraviolet radiation. Clearing of psoriasis occurred in 40 patients (78%) and marked improvement in 5 (10%). Of the remaining patients three (6%), who had generalized erythroderma, failed to respond to this therapy. The mean number of treatments required for clearing was 37.5. No serious side effects were noted clinically, by ophthalmologic examination or by laboratory testing. This therapy has some advantages over conventional types of treatment now used for severe psoriasis, but also has limitations. It appears to be an effective method of treatment for ambulatory patients. Further long-term follow-up studies are required to evaluate its side effects.
1976年5月至1977年9月期间，51例重度银屑病患者接受口服8-甲氧基补骨脂素治疗，随后接受高强度长波紫外线照射。40例患者（78%）银屑病皮损消退，5例（10%）显著改善。其余患者中，3例（6%）患有全身性红皮病，对该治疗无反应。皮损消退所需的平均治疗次数为37.5次。临床、眼科检查或实验室检测均未发现严重副作用。该疗法与目前用于治疗重度银屑病的传统疗法相比有一些优势，但也有局限性。它似乎是一种适用于门诊患者的有效治疗方法。需要进一步进行长期随访研究以评估其副作用。
